ADVOCIN is a veterinary injectable solution that contains Danofloxacin, a fluoroquinolone-class antibiotic, designed for the treatment of bacterial infections in livestock, primarily in cattle and swine. It is highly effective against a variety of Gram-negative and some Gram-positive bacteria. Advocin is particularly use to treat respiratory infections in cattle, including bovine respiratory disease (BRD), which is cause by pathogens like Mannheimia haemolytica and Pasteurella multocida. Buy advocin danofloxacin Injection

Active Ingredient: 

• Danofloxacin is a broad-spectrum fluoroquinolone antibiotic. It works by inhibiting bacterial DNA-gyrase, an enzyme critical for bacterial replication. This mechanism results in the rapid death of susceptible bacteria and the effective control of bacterial infections.
• Concentration: Each milliliter of Advocin contains 100 mg of Danofloxacin, making it a potent option for treating serious bacterial infections.

Primary Uses of Buy advocin danofloxacin Injection)

1. Bovine Respiratory Disease (BRD): One of the main applications of Advocin is the treatment of bovine respiratory disease, a condition common in feedlot cattle, especially after transportation. The disease is caused by a combination of viral infections and bacterial pathogens like Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni.
2. Bacterial Pneumonia in Swine: Advocin is also used to treat respiratory infections in swine caused by susceptible bacteria. This includes conditions like swine respiratory disease (SRD).
3. Other Systemic Infections: While its primary use is in respiratory infections, Advocin can be used for a variety of other bacterial infections caused by susceptible organisms.

Mechanism of Action

Danofloxacin, like other fluoroquinolones, targets and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. These enzymes are necessary for the replication and transcription of bacterial DNA. Without these enzymes, the bacteria are unable to reproduce, leading to their rapid death and the resolution of the infection.

Dosage and Administration

Advocin should only be administered under the guidance of a veterinarian, as the dosage and duration of treatment depend on the type and severity of the infection as well as the animal’s weight.

• Cattle (Beef and Non-Lactating Dairy Cattle): The recommended dose for treating BRD is 8 mg/kg of body weight, administered subcutaneously (SC) in the neck. Treatment can be repeated after 48 hours if necessary. The volume injected per site should not exceed 10 mL.
• Swine: For treating respiratory infections in swine, the dosage is typically based on body weight, and it’s administered via intramuscular injection. Always follow the veterinarian’s guidance for proper dosing in swine.

Important Consideration: Use sterile injection techniques and avoid injecting into inflamed areas to prevent irritation at the injection site.

Benefits of Advocin (Danofloxacin Injection)

1. Rapid Action: Danofloxacin is known for its fast-acting bactericidal properties, which make it highly effective in managing acute infections, particularly in the respiratory system.
2. Broad-Spectrum Activity: Its ability to treat a wide range of Gram-negative and some Gram-positive bacteria makes Advocin versatile and effective for various bacterial infections in livestock.
3. Low Injection Volume: Due to its potency, only a small injection volume is required, reducing the stress on animals and minimizing injection-site reactions.
4. Minimal Withdrawal Period: Advocin has a shorter withdrawal period compared to other antibiotics, allowing for quicker return of animals to the production chain.

Side Effects and Precautions

Although Advocin is generally well-tolerated, there are potential side effects and precautions that must be observed:

1. Injection Site Reactions: Animals may experience swelling or irritation at the injection site. This is usually mild and resolves on its own but should be monitored.
2. Antibiotic Resistance: The use of fluoroquinolones, like Danofloxacin, should be strictly regulated to avoid the development of antibiotic-resistant bacteria. This is particularly important due to the critical role fluoroquinolones play in both veterinary and human medicine.
3. Not for Use in Lactating Dairy Cattle: Advocin should not be administered to dairy cattle producing milk for human consumption, as fluoroquinolones are not approved for use in lactating dairy cows.
4. Avoid Use in Pregnant Animals: Caution is advise when administering to pregnant animals unless the benefit outweighs the risk.
5. Drug Interactions: Advocin may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs) and certain other antibiotics. So it is important to provide your veterinarian with a complete list of medications the animal may be taking.

Withdrawal Periods

• Cattle (Meat): The withdrawal period for cattle intended for human consumption is 4 days after the last administration of Advocin. This ensures that no harmful drug residues remain in the animal’s system.
• Swine (Meat): Similarly, in swine, a withdrawal period of 4 days must be observed before slaughtering for human consumption.

Note: Advocin is not approved for use in female dairy cattle 18 months of age or older. Including dry dairy cows, to avoid contamination of milk with drug residues.

Conclusion

ADVOCIN (Danofloxacin Injection) 250 mL is a potent and fast-acting antibiotic design for the treatment of serious bacterial infections. Particularly respiratory diseases in cattle and swine. Its broad-spectrum activity against key bacterial pathogens makes it an essential tool in combating diseases like bovine respiratory disease (BRD) and swine respiratory disease (SRD). When use under proper veterinary supervision. Advocin offers quick relief from bacterial infections. Promoting faster recovery and improving the overall health and productivity of livestock. Buy advocin danofloxacin Injection