Folltropin Alfa

Folltropin Alfa – Product Description

Product Name: Folltropin Alfa
Drug Class: Recombinant Follicle-Stimulating Hormone (rFSH)
Common Brand Names: Gonal-f®, Puregon®, Follistim®

Description:

Folltropin alfa is a recombinant form of human follicle-stimulating hormone (FSH) used in assisted reproductive technologies to stimulate ovarian follicle development in women undergoing fertility treatments. It is manufactured using recombinant DNA technology, ensuring high purity, consistency, and reduced risk of immunogenic reactions compared to urinary-derived FSH products.

Folltropin alfa acts on the ovaries to stimulate the growth and maturation of multiple follicles, which is essential in protocols such as in vitro fertilization (IVF), intrauterine insemination (IUI), and ovulation induction.

Indications:

• Controlled ovarian stimulation in women undergoing ART (e.g., IVF)

• Induction of ovulation in anovulatory women

• Treatment of infertility due to hypogonadotropic hypogonadism (in combination with LH)

• Spermatogenesis stimulation in men with pituitary or hypothalamic disorders (off-label in some regions)

Key Features:

• Recombinant DNA origin – eliminates variability and contaminants found in urine-derived hormones

• High bioactivity and potency

• Prefilled injection pens and vials for ease of administration and dose accuracy

• Subcutaneous administration with flexible dosing protocols

Dosage and Administration:

• Administered via subcutaneous injection

• Starting dose and treatment duration vary depending on the patient’s diagnosis, response to therapy, and treatment protocol

• Requires monitoring of estradiol levels and follicular development via ultrasound

Note: Should be used only under the supervision of a fertility specialist or reproductive endocrinologist.

Storage:

• Store refrigerated at 2°C to 8°C (36°F to 46°F)

• Can be stored at room temperature (up to 25°C/77°F) for a limited period, depending on the manufacturer’s guidelines

Precautions:

• Monitor closely for ovarian hyperstimulation syndrome (OHSS)

• Contraindicated in patients with ovarian enlargement of unknown cause, primary ovarian failure, or pituitary tumors

• Not indicated in postmenopausal women

Conclusion:

Folltropin alfa is a trusted and widely used fertility medication that delivers precise and effective stimulation for women undergoing fertility treatments. Its advanced recombinant formulation offers superior purity and consistency, making it a cornerstone in modern reproductive medicine.